Chronos Integration Update

Alderley Park, 2 May 2024 - TheraCryf plc (AIM: TCF), formerly Evgen Pharma plc, the clinical stage drug development company focussing on oncology and neuropsychiatry, provides an update on the integration of Chronos Therapeutics Ltd (Chronos) further to the announcements on 19th March and 25th April 2024. This update follows the acquisition, accompanying placing and results of the Company's general meeting approving the issuance of shares and, as of 25 April 2024, the change of name to TheraCryf plc and the AIM ticker to TCF.

The following actions have taken place to date:

• Transaction effective from 5 April 2024
• Former Chronos shareholders received 62'291'778 shares as the first consideration
• Transition of Chronos to a wholly owned affiliate of TheraCryf complete
• Board members of Chronos stepped down as pre-agreed
• Toni Haenninen and Dr Huw Jones appointed directors of Chronos effective 19 April 2024
• Email and website (www.theracryf.com) transition complete
• Transfer of records, technical study reports and financial systems well advanced

Dr Huw Jones, CEO of TheraCryf, said

"Many thanks to the TheraCryf team for executing the transition in a speedy and efficient way. I would also like to thank the members of the board of Chronos for their important part in the transaction and the transition of Chronos to become part of the TheraCryf Group.

"We strongly believe that having additional scale and a broadened pipeline of development programmes will enhance shareholder value considerably. We are focussed on our entire portfolio, comprising our SFX-01 programme in glioblastoma and autism, our Orexin-1 antagonist in impulsivity and addiction, and our atypical DAT inhibitor in fatigue and narcolepsy. In common with the non-dilutive funding already in place for SFX-01 in glioblastoma, we are actively seeking non-dilutive funding for our acquired programmes."

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