SFX-01 positive update in bowel cancer models

Alderley Park, UK - 27 February 2024: Evgen Pharma plc (AIM: EVG), the clinical stage drug development company developing sulforaphane-based medicines for the treatment of multiple diseases, announces that the laboratories of Professor Grace Chen, Associate Professor Justin Colacino, and Professor Duxin Sun at the University of Michigan, USA have observed activity of SFX-01 in models of colon cancer.

The in vitro and in vivo studies, funded by the USA National Cancer Institute and the University of Michigan will be generating data continuously throughout the project.

According to one of the lead investigators, Professor Chen of the Division of Hematology and Oncology, Department of Internal Medicine at the University of Michigan Medical School:

"We have shown preliminary signs of anti-tumour activity of SFX-01 in organoids derived from human tumours."

Dr Huw Jones, CEO of Evgen Pharma said:

"These early data from our collaborators in the USA show encouraging evidence of activity of SFX-01 in another significant cancer. Colorectal or bowel cancer is the third most common cancer worldwide accounting for around one in ten of all cancer diagnoses and a cause of significant morbidity and mortality. We look forward to continuing to work with Prof Chen and colleagues to learn more about SFX-01 in this setting."

The Company also has a wide number of collaborations with leading academic centres in the UK, Europe and the US as part of the continuing strategy to build the scientific data for the compound. Recently, Evgen completed an out-licensing transaction with Stalicla SA, a Swiss specialist company in neurodevelopmental disorders, commencing with autism spectrum disorder. The deal, if successful, will generate milestone payments of $160.5m and a double-digit royalty on sales.

For further information, please visit: www.evgen.com.