Exercise of Warrants

Cambridge, UK, 7 May 2024 - Sareum Holdings plc (AIM: SAR), a clinical-stage biotechnology company developing next-generation kinase inhibitors for autoimmune disease and cancer, announces that it has received an exercise of warrants notice from RiverFort Global Opportunities PCC Ltd ("RiverFort") to subscribe for a total of 1,106,986 new ordinary shares in the capital of the Company (the "New Ordinary Shares") at a price of 10 pence per New Ordinary Share for a total consideration to the Company of £110,698.60.

As announced on 3 August 2023, the warrants were issued in connection with the Equity Prepayment Facility (the "RiverFort Facility") provided by RiverFort to the Company. Following this exercise of warrants, RiverFort hold zero warrants over shares in the Company.

As noted in Sareum's announcement of 23 April 2024, the Company has settled the full outstanding balance of, and does not intend to make any further withdrawals pursuant to, the RiverFort Facility.

Admission and Total Voting Rights

Application has been made to the London Stock Exchange plc for the admission of the 1,106,986 New Ordinary Shares to trading on AIM ("Admission"). It is expected that Admission will occur at 8.00 a.m. (London time) on or around Monday 13 May 2024. The New Ordinary Shares will rank pari passu with the existing ordinary shares.

Immediately following Admission, the total number of ordinary shares in issue will be 107,945,783 and the total number of voting rights will therefore be 107,945,783, and this figure may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the share capital of the Company under the FCA's Disclosure and Transparency Rules.