Final Issue of RiverFort Subscription Shares

Cambridge, UK, 23 April 2024 - Sareum Holdings plc (AIM: SAR), a clinical-stage biotechnology company developing next-generation kinase inhibitors for autoimmune disease and cancer, announces that it has issued 2,260,488 new Ordinary Shares in the capital of the Company to RiverFort Global Opportunities PCC Ltd (the "Riverfort Shares"), in accordance with the terms of the Facility announced on 3 August 2023 (the "Riverfort Facility").

The issuance of the Riverfort Shares will settle the full outstanding balance on the Riverfort Facility. As noted in Sareum's announcement of 28 March 2024, the Company does not intend to make any further withdrawals pursuant to the Riverfort Facility and accordingly the Company will not be issuing any further Subscription Shares pursuant to the Riverfort Facility.

Admission and Total Voting Rights

Application has been made to the London Stock Exchange plc for the admission of 2,260,488 new Ordinary Shares to trading on AIM ("Admission"). It is expected that Admission will occur at 8.00 a.m. (London time) on or around Friday 26 April 2024.

Immediately following Admission, the total number of Ordinary Shares in issue will be 106,838,797 and the total number of voting rights will therefore be 106,838,797, and this figure may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the share capital of the Company under the FCA's Disclosure and Transparency Rules.