New Patent Allowance

Cambridge, UK, 15 March 2024 - Sareum Holdings plc (AIM: SAR), a clinical-stage biotechnology company developing next-generation kinase inhibitors for autoimmune disease and cancer, today announces that the European Patent Office has issued a Notice of Allowance for a patent relating to SDC‐1801, the Company's lead TYK2/JAK1 kinase inhibitor, currently in clinical development in Australia.

The newly approved European patent application, EP3864009, safeguards SDC‐1801, its medical applications particularly in the treatment of autoimmune diseases, and certain methods of synthesis.

This follows approvals in 2023 by the China National Intellectual Property Administration, and the Japan Patent Office for the same protections.

Patent applications in the US (US2021387981) and other territories are still under review.

The Company expects that the patent will be granted in the near future, subject to certain formalities being completed.

Dr John Reader, Sareum's Chief Scientific Officer, commented: "This new patent allows us to enhance our intellectual property portfolio in a crucial market. Our Phase 1a trial for SDC-1801 in Australia is progressing smoothly, with the Single Ascending Dose (SAD) and Food Effect study revealing no significant adverse events. This progress highlights the potential of SDC-1801 to achieve therapeutic drug levels in the bloodstream through once-daily oral dosing."