Holding(s) in Company
Renalytix plc received six TR-1 notifications from Heights Capital Management Inc. between September 22, 2025, and October 7, 2025, regarding changes in voting rights. On September 22, 2025, Heights Capital Management Inc.'s voting rights attached to shares were 8.86% representing 29,350,000 voting rights. This decreased to 7.35% with 24,350,000 voting rights on September 25, 2025, and further to 5.39% with 21,850,000 voting rights on September 26, 2025. By September 29, 2025, the voting rights were 4.96% equivalent to 20,100,000. A subsequent decrease occurred on October 2, 2025, bringing the voting rights to 3.90% with 15,823,655 voting rights. The most recent notification on October 7, 2025, indicates a further decrease to 2.96% with 12,001,499 voting rights.
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LONDON and NEW YORK, 10 October 2025 - Renalytix plc (LSE: RENX) (OTCQB: RNLXY), announces that it has received six TR-1 notifications from Heights Capital Management Inc., covering the period 22 September 2025 to 7 October 2025, which are reproduced below with the most recent TR-1 notification first.
(#1) TR-1: Standard form for notification of major holdings
- Please indicate if the issuer is a non-UK issuer (please mark with an "X" if appropriate)
Non-UK issuer
- Reason for the notification (please mark the appropriate box or boxes with an "X")
| An acquisition or disposal of voting rights | X |
An acquisition or disposal of financial instruments
An event changing the breakdown of voting rights
Other (please specify) iii :
Details of person subject to the notification obligation iv
| Name | Heights Capital Management, Inc. |
| City and country of registered office (if applicable) | San Francisco, California |
Full name of shareholder(s) (if different from 3.) v
| Name | CVI Investments, Inc. |
| City and country of registered office (if applicable) | Cayman Islands |
| 5. Date on which the threshold was crossed or reached vi : | 07/10/2025 |
| 6. Date on which issuer notified (DD/MM/YYYY): | 08/10/2025 |
- Total positions of person(s) subject to the notification obligation
| Resulting situation on the date on which threshold was crossed or reached | 2.96% | 0.00% | 2.96% | 12,001,499 |
| Position of previous notification (if applicable) | 3.90% | 0.00% | 3.90% | |
| A: Voting rights attached to shares | ||||
| Class/type of shares ISIN code (if possible) | Number of voting rights ix | % of voting rights | ||
| Direct (DTR5.1) | Indirect (DTR5.2.1) | Direct (DTR5.1) | Indirect (DTR5.2.1) | |
| GB00BYWL4Y04 | 12,001,499 | 2.96% | ||
| SUBTOTAL 8. A | 12,001,499 | 2.96% | ||
B 1: Financial Instruments according to DTR5.3.1R (1) (a)
SUBTOTAL 8. B 1
B 2: Financial Instruments with similar economic effect according to DTR5.3.1R (1) (b)
SUBTOTAL 8.B.2
| Heights Capital Management, Inc. | 2.96% | 2.96% |
| CVI Investments, Inc. | 2.96% | 2.96% |
In case of proxy voting, please identify:
Name of the proxy holder
The number and % of voting rights held
The date until which the voting rights will be held
Additional information xvi
None
| Place of completion | London, United Kingdom |
|---|---|
| Date of completion | 08.10.2025 |
(#2) TR-1: Standard form for notification of major holdings
- Please indicate if the issuer is a non-UK issuer (please mark with an "X" if appropriate)
Non-UK issuer
- Reason for the notification (please mark the appropriate box or boxes with an "X")
| An acquisition or disposal of voting rights | X |
An acquisition or disposal of financial instruments
An event changing the breakdown of voting rights
Other (please specify) iii :
Details of person subject to the notification obligation iv
| Name | Heights Capital Management, Inc. |
| City and country of registered office (if applicable) | San Francisco, California |
Full name of shareholder(s) (if different from 3.) v
| Name | CVI Investments, Inc. |
| City and country of registered office (if applicable) | Cayman Islands |
| 5. Date on which the threshold was crossed or reached vi : | 02/10/2025 |
| 6. Date on which issuer notified (DD/MM/YYYY): | 03/10/2025 |
- Total positions of person(s) subject to the notification obligation
| Resulting situation on the date on which threshold was crossed or reached | 3.90% | 0.00% | 3.90% | 15,823,655 |
| Position of previous notification (if applicable) | 4.96% | 0.00% | 4.96% | |
| A: Voting rights attached to shares | ||||
| Class/type of shares ISIN code (if possible) | Number of voting rights ix | % of voting rights | ||
| Direct (DTR5.1) | Indirect (DTR5.2.1) | Direct (DTR5.1) | Indirect (DTR5.2.1) | |
| GB00BYWL4Y04 | 15,823,655 | 3.90% | ||
| SUBTOTAL 8. A | 15,823,655 | 3.90% | ||
B 1: Financial Instruments according to DTR5.3.1R (1) (a)
SUBTOTAL 8. B 1
B 2: Financial Instruments with similar economic effect according to DTR5.3.1R (1) (b)
SUBTOTAL 8.B.2
| Heights Capital Management, Inc. | 3.90% | 3.90% |
| CVI Investments, Inc. | 3.90% | 3.90% |
In case of proxy voting, please identify:
Name of the proxy holder
The number and % of voting rights held
The date until which the voting rights will be held
Additional information xvi
None
| Place of completion | London, United Kingdom |
|---|---|
| Date of completion | 03.10.2025 |
(#3) TR-1: Standard form for notification of major holdings
- Please indicate if the issuer is a non-UK issuer (please mark with an "X" if appropriate)
Non-UK issuer
- Reason for the notification (please mark the appropriate box or boxes with an "X")
| An acquisition or disposal of voting rights | X |
An acquisition or disposal of financial instruments
An event changing the breakdown of voting rights
Other (please specify) iii :
Details of person subject to the notification obligation iv
| Name | Heights Capital Management, Inc. |
| City and country of registered office (if applicable) | San Francisco, California |
Full name of shareholder(s) (if different from 3.) v
| Name | CVI Investments, Inc. |
| City and country of registered office (if applicable) | Cayman Islands |
| 5. Date on which the threshold was crossed or reached vi : | 29/09/2025 |
| 6. Date on which issuer notified (DD/MM/YYYY): | 29/09/2025 |
- Total positions of person(s) subject to the notification obligation
| Resulting situation on the date on which threshold was crossed or reached | 4.96% | 0.00% | 4.96% | 20,100,000 |
| Position of previous notification (if applicable) | 5.39% | 0.00% | 5.39% | |
| A: Voting rights attached to shares | ||||
| Class/type of shares ISIN code (if possible) | Number of voting rights ix | % of voting rights | ||
| Direct (DTR5.1) | Indirect (DTR5.2.1) | Direct (DTR5.1) | Indirect (DTR5.2.1) | |
| GB00BYWL4Y04 | 20,100,000 | 4.96% | ||
| SUBTOTAL 8. A | 20,100,000 | 4.96% | ||
B 1: Financial Instruments according to DTR5.3.1R (1) (a)
SUBTOTAL 8. B 1
B 2: Financial Instruments with similar economic effect according to DTR5.3.1R (1) (b)
SUBTOTAL 8.B.2
| Heights Capital Management, Inc. | 4.96% | 4.96% |
| CVI Investments, Inc. | 4.96% | 4.96% |
In case of proxy voting, please identify:
Name of the proxy holder
The number and % of voting rights held
The date until which the voting rights will be held
Additional information xvi
None
| Place of completion | London, United Kingdom |
|---|---|
| Date of completion | 29.09.2025 |
(#4) TR-1: Standard form for notification of major holdings
- Please indicate if the issuer is a non-UK issuer (please mark with an "X" if appropriate)
Non-UK issuer
- Reason for the notification (please mark the appropriate box or boxes with an "X")
| An acquisition or disposal of voting rights | X |
An acquisition or disposal of financial instruments
An event changing the breakdown of voting rights
Other (please specify) iii :
Details of person subject to the notification obligation iv
| Name | Heights Capital Management, Inc. |
| City and country of registered office (if applicable) | San Francisco, California |
Full name of shareholder(s) (if different from 3.) v
| Name | CVI Investments, Inc. |
| City and country of registered office (if applicable) | Cayman Islands |
| 5. Date on which the threshold was crossed or reached vi : | 26/09/2025 |
| 6. Date on which issuer notified (DD/MM/YYYY): | 29/09/2025 |
- Total positions of person(s) subject to the notification obligation
| Resulting situation on the date on which threshold was crossed or reached | 5.39% | 0.00% | 5.39% | 21,850,000 |
| Position of previous notification (if applicable) | 7.35% | 0.00% | 7.35% | |
| A: Voting rights attached to shares | ||||
| Class/type of shares ISIN code (if possible) | Number of voting rights ix | % of voting rights | ||
| Direct (DTR5.1) | Indirect (DTR5.2.1) | Direct (DTR5.1) | Indirect (DTR5.2.1) | |
| GB00BYWL4Y04 | 21,850,000 | 5.39% | ||
| SUBTOTAL 8. A | 21,850,000 | 5.39% | ||
B 1: Financial Instruments according to DTR5.3.1R (1) (a)
SUBTOTAL 8. B 1
B 2: Financial Instruments with similar economic effect according to DTR5.3.1R (1) (b)
SUBTOTAL 8.B.2
| Heights Capital Management, Inc. | 5.39% | 5.39% |
| CVI Investments, Inc. | 5.39% | 5.39% |
In case of proxy voting, please identify:
Name of the proxy holder
The number and % of voting rights held
The date until which the voting rights will be held
Additional information xvi
None
| Place of completion | London, United Kingdom |
|---|---|
| Date of completion | 29.09.2025 |
(#5) TR-1: Standard form for notification of major holdings
- Please indicate if the issuer is a non-UK issuer (please mark with an "X" if appropriate)
Non-UK issuer
- Reason for the notification (please mark the appropriate box or boxes with an "X")
| An acquisition or disposal of voting rights | X |
An acquisition or disposal of financial instruments
An event changing the breakdown of voting rights
Other (please specify) iii :
Details of person subject to the notification obligation iv
| Name | Heights Capital Management, Inc. |
| City and country of registered office (if applicable) | San Francisco, California |
Full name of shareholder(s) (if different from 3.) v
| Name | CVI Investments, Inc. |
| City and country of registered office (if applicable) | Cayman Islands |
| 5. Date on which the threshold was crossed or reached vi : | 25/09/2025 |
| 6. Date on which issuer notified (DD/MM/YYYY): | 29/09/2025 |
- Total positions of person(s) subject to the notification obligation
| Resulting situation on the date on which threshold was crossed or reached | 7.35% | 0.00% | 7.35% | 24,350,000 |
| Position of previous notification (if applicable) | 8.86% | 0.00% | 8.86% | |
| A: Voting rights attached to shares | ||||
| Class/type of shares ISIN code (if possible) | Number of voting rights ix | % of voting rights | ||
| Direct (DTR5.1) | Indirect (DTR5.2.1) | Direct (DTR5.1) | Indirect (DTR5.2.1) | |
| GB00BYWL4Y04 | 24,350,000 | 7.35% | ||
| SUBTOTAL 8. A | 24,350,000 | 7.35% | ||
B 1: Financial Instruments according to DTR5.3.1R (1) (a)
SUBTOTAL 8. B 1
B 2: Financial Instruments with similar economic effect according to DTR5.3.1R (1) (b)
SUBTOTAL 8.B.2
| Heights Capital Management, Inc. | 7.35% | 7.35% |
| CVI Investments, Inc. | 7.35% | 7.35% |
In case of proxy voting, please identify:
Name of the proxy holder
The number and % of voting rights held
The date until which the voting rights will be held
Additional information xvi
None
| Place of completion | London, United Kingdom |
|---|---|
| Date of completion | 29.09.2025 |
(#6) TR-1: Standard form for notification of major holdings
- Please indicate if the issuer is a non-UK issuer (please mark with an "X" if appropriate)
Non-UK issuer
- Reason for the notification (please mark the appropriate box or boxes with an "X")
| An acquisition or disposal of voting rights | X |
An acquisition or disposal of financial instruments
An event changing the breakdown of voting rights
Other (please specify) iii :
Details of person subject to the notification obligation iv
| Name | Heights Capital Management, Inc. |
| City and country of registered office (if applicable) | San Francisco, California |
Full name of shareholder(s) (if different from 3.) v
| Name | CVI Investments, Inc. |
| City and country of registered office (if applicable) | Cayman Islands |
| 5. Date on which the threshold was crossed or reached vi : | 22/09/2025 |
| 6. Date on which issuer notified (DD/MM/YYYY): | 29/09/2025 |
- Total positions of person(s) subject to the notification obligation
| Resulting situation on the date on which threshold was crossed or reached | 8.86% | 0.00% | 8.86% | 29,350,000 |
| Position of previous notification (if applicable) | 9.77% | 0.00% | 9.77% | |
| A: Voting rights attached to shares | ||||
| Class/type of shares ISIN code (if possible) | Number of voting rights ix | % of voting rights | ||
| Direct (DTR5.1) | Indirect (DTR5.2.1) | Direct (DTR5.1) | Indirect (DTR5.2.1) | |
| GB00BYWL4Y04 | 29,350,000 | 8.86% | ||
| SUBTOTAL 8. A | 29,350,000 | 8.86% | ||
B 1: Financial Instruments according to DTR5.3.1R (1) (a)
SUBTOTAL 8. B 1
B 2: Financial Instruments with similar economic effect according to DTR5.3.1R (1) (b)
SUBTOTAL 8.B.2
| Heights Capital Management, Inc. | 8.86% | 8.86% |
| CVI Investments, Inc. | 8.86% | 8.86% |
In case of proxy voting, please identify:
Name of the proxy holder
The number and % of voting rights held
The date until which the voting rights will be held
Additional information xvi
None
| Place of completion | London, United Kingdom |
|---|---|
| Date of completion | 29.09.2025 |
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