Contract Signed with Leading Global CRO

LONDON, U.K. AND NEW YORK, U.S. (22 October 2025). Trellus Health® plc (AIM: TRLS), a healthcare company delivering Trellus Elevate®, a digital platform that integrates data analytics with personalised, scientifically proven resilience programs and value-based solutions to manage complex chronic conditions, announces that, further to yesterday's announcement that it is in late stage contracting discussions, it has signed a 12 month contract (the "Contract") with one of the largest global Clinical Research Organisations (CROs), to support recruitment and enrolment optimisation for an ongoing mid-stage clinical trial in the field of immunology and inflammation. The Contract is due to commence later this year.

The clinical trials sector remains a strategic growth area for the Group and, accordingly, the Company has launched Trellus TrialSet™. This program is designed to support potential clinical trial participants by identifying individuals with low resilience, who may be hesitant to enrol in the trial, and provide structured services to strengthen their readiness.

By leveraging the Company's proprietary resilience methodology alongside behavioural science, tailored education, and personalised engagement, Trellus TrialSet™ enables participants to move from uncertainty to confidence, ensuring they are prepared to successfully enter and remain in the trial. This is expected to enhance recruitment efficiency, improve retention, and deliver cost savings for partners. The Contract, which includes an upfront fee, a monthly management fee, and milestone payments, is structured around three key performance indicators: (i) the number of potential eligible participants opting into the Trellus TrialSet™ programme, (ii) the increase in qualified participants referred for screening, and (iii) the reduction in the screen failure rate.

As further announced yesterday, Trellus Health® has also now been granted preferred vendor status ("Preferred Vendor Status") by a second leading global contract research organisation (CRO) and negotiations continue to support recruitment for an additional clinical program. Whilst the granting of Preferred Vendor Status is not revenue generating in itself, it reinforces the strength and differentiation of Trellus Health's offering in the clinical trials vertical and provides direct access to the CRO's client base as well as accelerating procurement and contracting timelines.

• Marla Dubinsky, Chief Executive Officer of Trellus Health, said: "Clinical trials continue to face challenges in recruitment, retention and study completion. We are proud to launch Trellus TrialSet™ to directly address these issues by proactively assessing and preparing participants, ensuring only those who are ready will enter the trial. This resilience-based approach is designed to significantly reduce screen failures and dropouts while delivering meaningful cost savings for our partners.

We are pleased to announce this partnership with a leading global CRO. While it does not immediately extend the Company's current cash runway beyond early December, it reflects our ability to secure contracts with leading CROs and represents an important step in building commercial traction. In addition, our designation as a preferred vendor by a second leading CRO for supporting recruitment for an additional clinical trial program further strengthens our position in the clinical trial vertical.

We will provide further updates in due course, as appropriate."

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