Manufacturing Scale Up of Lead Ox-1 Programme

Alderley Park, 17 July 2025 - TheraCryf plc (AIM: TCF), the clinical stage drug development company focussing on brain disorders, provides an update on key activity in its Ox-1 development programme.

At the recent AGM the Company gave an update on its lead asset Ox-1, TheraCryf's orexin 1 antagonist in addictive behaviours, highlighting the on-track progress made following the fundraising in March of this year to take the programme to clinical readiness.

The Company now reports that manufacturing and early development partner, Pharmaron, has initiated the manufacturing scale up of the active pharmaceutical ingredient (API) of the lead programme, Ox-1, on-time and to-plan. The production of the demonstration and toxicology batches, at 0.5kg and 10kg scale, respectively, are key milestones in the development programme. These batches will produce sufficient quantities of product for formulation, characterisation and toxicology, all of which are essential for inclusion in the regulatory documentation for obtaining permission to conduct trials in people.

Dr Helen Kuhlman, CBO of TheraCryf commented:

"Manufacturing at scale for the first time represents a major step forward in any development programme at this stage. The start of this activity by our early development partner on time is another demonstration of our confidence in both the programme and our management of it. Unlocking the considerable future value of our addiction programme is our first priority given the large addressable market for our Ox-1 asset."