Research Coverage Initiation

LONDON - 13 July 2026 - Solvonis Therapeutics plc (LSE: SVNS), a late clinical-stage biopharmaceutical company developing novel small-molecule therapeutics for high-burden central nervous system ("CNS") disorders, announces that US-based Water Tower Research LLC ("WTR") has initiated research coverage of the Company.

The report, entitled "SVNS: Pursuing Acute Intervention Rather Than Chronic Treatment of High-Burden CNS Conditions", provides investors with a US capital-markets perspective on Solvonis' clinical-stage programmes, addressable markets and valuation relative to relevant publicly traded addiction and advanced-stage CNS companies.

WTR highlights the valuation opportunity presented by Solvonis' current market capitalisation relative to relevant peer companies. At the time of publication, WTR recorded Solvonis' market value at approximately US$15 million and benchmarked the Company against:

• selected US-listed advanced-stage CNS companies valued between approximately US$369 million and US$5.9 billion;
• Altimmune, an AUD-active clinical-stage company valued at approximately US$600 million;
• Indivior, a commercial addiction-medicine company valued at approximately US$5 billion; and
• the proposed European commercialisation framework for Adial Pharmaceuticals' pre-Phase 3 AUD asset, which outlined upfront consideration, development and commercial milestone payments and tiered royalties, with total potential value of up to approximately US$60 million, subject to clinical success and commercialisation.

Solvonis is currently advancing a Phase 3 programme, a US-focused clinical-stage programme preparing for Phase 2b development and a proprietary CNS discovery pipeline.

WTR also highlights the scale of the Alcohol Use Disorder ("AUD") opportunity addressed by Solvonis, including:

• approximately 27.9 million people aged 12 and over with AUD in the United States;
• an estimated 11-12 million people with moderate-to-severe AUD in the US target market for SVN-002;
• an estimated 13 million people with severe AUD across the UK and selected European markets addressed by SVN-001; and
• an economic burden measured in the hundreds of billions of dollars across the Company's principal target markets.

The report positions Solvonis within the US CNS investment universe and identifies progression of SVN-002 towards a US Phase 2b trial, increased engagement with US capital markets and broader access to US investors, and the future SVN-001 Phase 3 readout as important potential value inflection points.

The initiation of US research coverage forms part of Solvonis' broader engagement with US investors and capital markets as the Company advances SVN-002, its US-focused esketamine oral thin-film programme for moderate-to-severe AUD.

The full report is available free of charge through Water Tower Research following registration.

WTR has been engaged and compensated by Solvonis to provide ongoing research coverage. WTR does not provide investment ratings, recommendations or price targets. The analysis, forecasts and opinions contained in the report are those of WTR.