Notice of AGM, Annual Report and Accounts

Cambridge, UK, 17 November 2025 - Sareum Holdings plc (AIM: SAR), a clinical-stage biotechnology company developing next-generation kinase inhibitors for autoimmune disease and cancer, today announces that the Company's Annual General Meeting ("AGM") will be held at 10.00am GMT on Tuesday 9 December 2025 at the offices of ICR Healthcare, 85 Gresham Street, London EC2V 7NQ.

In order to allow shareholders to follow the proceedings of the AGM without attending in person, the Company will provide access online via the Investor Meet Company ("IMC") platform. Shareholders who wish to attend the AGM remotely should register for the event in advance by using the following link: https://www.investormeetcompany.com/sareum-holdings-plc/register-investor. Investors who already follow Sareum Holdings plc on the IMC platform will automatically be invited.

Shareholders are invited to submit questions for the Board to consider in the Q&A session to be held immediately after the AGM. Questions can be pre submitted via the IMC Platform up until 8 December 2025, 9.00am GMT and can be submitted at any time during the AGM itself. Shareholders are reminded that they will not be able to vote online at the AGM via the IMC platform and are therefore requested to submit their votes via proxy, as early as possible.

The notice of AGM, along with a copy of the Company's annual report and accounts for the year ended 30 June 2025, will be posted shortly to those shareholders who requested a hard copy. A copy of both documents will also be available on the Company's website: www.sareum.com in the Investor Relations section.