WRAP Retail Offer for up to £110,000.00

Physiomics plc (AIM: PYC), a leading mathematical modelling, data science and biostatistics company supporting the development of new therapeutics and personalised medicine solutions is pleased to announce a revised retail offer via the Winterflood Retail Access Platform ("WRAP") to raise up to £110,000.00 (the "WRAP Retail Offer") through the issue of new ordinary shares ("Ordinary Shares"). Under the WRAP Retail Offer up to 27,500,000 new Ordinary Shares (the "WRAP Retail Offer Shares") will be made available at a price of £0.004 per share.

A separate announcement has been made regarding the Placing and its terms and sets out the reasons for the Placing and use of proceeds. That announcement also sets out information relating to the cancellation of the placing and retail offer that were announced on 10 March 2026.

In addition to the WRAP Retail Offer and as announced today, the Company is also proposing a revised placing of new Ordinary Shares (the "Placing Shares" and together with the WRAP Retail Offer Shares, the "New Ordinary Shares") to raise £490,000.00 (before expenses) through a bookbuild process (the "Placing") at an issue price of £0.004 per Placing Share (the "Placing Price"). The Placing Price represents a discount of approximately 14 per cent. to the mid-market closing price of an existing ordinary share on 16 March 2026 (being the latest practicable date prior to this announcement).

The issue price of the WRAP Retail Offer Shares is equal to the Placing Price.

The WRAP Retail Offer and the Placing are conditional on the New Ordinary Shares being admitted to trading on AIM ("Admission"). It is anticipated that Admission will become effective and that dealings in the New Ordinary Shares will commence at 8.00 a.m. on or around 20 March 2026.

WRAP Retail Offer

The Company values its retail shareholder base and believes that it is appropriate to provide its existing retail shareholders in the United Kingdom the opportunity to participate in in its fundraising on the same terms as the participants of the Placing.

Accordingly, the Company is making the WRAP Retail Offer available to eligible investors in the United Kingdom, being existing shareholders of Physiomics plc, following release of this announcement and through certain financial intermediaries.

The WRAP Retail Offer is expected to close at midday on 18 March 2026. Eligible shareholders should note that financial intermediaries may have earlier closing times.

There is a minimum subscription of £100 per investor under the WRAP Retail Offer. The terms and conditions on which investors subscribe will be provided by the relevant financial intermediaries including relevant commission or fee charges.

No offering document, prospectus or admission document has been or will be prepared or submitted to be approved by the FCA (or any other authority) in relation to the WRAP Retail Offer, and investors' commitments will be made solely on the basis of the information contained in this announcement and information that has been published by or on behalf of the Company prior to the date of this announcement by notification to a Regulatory Information Service in accordance with the FCA's Disclosure Guidance and Transparency Rules, the Market Abuse Regulation (EU Regulation No. 596/2014) ("MAR") and MAR as it forms part of United Kingdom law by virtue of the European Union (Withdrawal) Act 2018 (as amended).

The Company's LEI is 213800A71DSZ6ABMTQ91.

UK Product Governance Requirements