PRTC's SPTX: New Positive Phase 1 GlyphAllo Data

PureTech Founded Entity Seaport Therapeutics Reports Positive Topline Results from Phase 1 Driving Simulation Trial of GlyphAllo™ in Healthy Volunteers

PureTech Health plc (LSE: PRTC) ("PureTech" or the "Company"), a hub-and-spoke biotherapeutics company dedicated to giving life to science and transforming innovation into value, notes that its Founded Entity, Seaport Therapeutics, today announced positive topline results from the Phase 1 Driving Simulation Trial of GlyphAllo™ (SPT-300 or Glyph Allopregnanolone) in healthy volunteers. The trial met its primary endpoint, demonstrating that evening dosing of GlyphAllo at 375 mg did not impair next-morning driving performance compared to placebo on Day 5, following multiple-day dosing. Seaport plans to submit the results to the U.S. Food and Drug Administration as part of the ongoing development program for GlyphAllo.

GlyphAllo is a novel, Glyphed oral prodrug of allopregnanolone in development for the potential treatment of major depressive disorder (MDD). Seaport is actively enrolling patients in BUOY-1, a two-arm, global, randomized, double-blind, placebo-controlled, potentially registration-enabling Phase 2b trial investigating the safety and efficacy of GlyphAllo in patients with MDD, with or without anxious distress. Seaport expects to announce topline data from the BUOY-1 trial in the first half of 2027.

The full text of the announcement from Seaport is as follows:

Seaport Therapeutics Reports Positive Topline Results from Phase 1 Driving Simulation Trial of GlyphAllo™ in Healthy Volunteers

Trial met its primary endpoint, showing that evening dosing of GlyphAllo at 375 mg did not impair next-morning driving performance compared to placebo on Day 5, following multiple-day dosing

Key secondary endpoint also met, showing a single evening dose of 250 mg GlyphAllo did not impair next-morning driving performance compared to placebo on Day 2

GlyphAllo was well-tolerated, with no serious adverse events reported

Company plans to submit results to the U.S. Food and Drug Administration as part of the ongoing development program for GlyphAllo

BOSTON, Sep. 9, 2026 -- Seaport Therapeutics, Inc., (Nasdaq: SPTX) ("Seaport" or the "Company"), a clinical-stage therapeutics company that is inventing and developing novel neuropsychiatric medicines, today announced positive topline results from the Phase 1 Driving Simulation Trial of GlyphAllo™ (SPT-300 or Glyph Allopregnanolone), a novel, Glyphed oral prodrug of allopregnanolone, in healthy volunteers. The trial evaluated the 375 mg dose of GlyphAllo, the highest dose currently being investigated in the Phase 2b BUOY-1 trial, as well as a 250 mg dose. The trial met its primary endpoint demonstrating that evening dosing of GlyphAllo at 375 mg did not impair next-morning driving performance compared to placebo on Day 5, following multiple-day dosing. The key secondary endpoint was also met, showing that a single 250 mg dose of GlyphAllo did not impair next-morning driving performance compared to placebo on Day 2.

"We are very pleased by the results which showed no next-morning driving impairment at either dose evaluated. The trial used a validated driving simulator and trial design with an evening dosing regimen consistent with the Phase 2b BUOY-1 trial and GlyphAllo's intended clinical use," said Daphne Zohar, Co-founder and Chief Executive Officer of Seaport Therapeutics. "We believe that GlyphAllo has the potential to deliver the benefits of allopregnanolone without next-morning effects on driving. These results further reinforce our view that GlyphAllo offers meaningful differentiation as we advance it as a potential first-in-class treatment for major depressive disorder."

The trial also included a 7.5 mg dose of zopiclone as the positive control. Zopiclone did produce statistically significant impairment relative to both GlyphAllo and placebo on both Day 2 and Day 5, confirming the assay sensitivity of the trial and its ability to detect an effect on driving performance. GlyphAllo was well-tolerated at all doses, with most adverse events being mild and transient and no serious adverse events reported. Together with previously generated clinical and preclinical data and a favorable safety and tolerability profile observed to date, these findings provide additional support for the differentiation of the overall profile of GlyphAllo as the program advances in the ongoing potentially registration-enabling trial in major depressive disorder (MDD).

Seaport plans to submit the results to the U.S. Food and Drug Administration as part of the ongoing development program for GlyphAllo. The Company also plans to present additional analyses at upcoming scientific meetings.

Seaport is actively enrolling patients in BUOY-1, a two-arm, global, randomized, double-blind, placebo-controlled, potentially registration-enabling Phase 2b trial investigating the safety and efficacy of GlyphAllo in patients with MDD, with or without anxious distress. The Company expects to announce topline data from the BUOY-1 trial in the first half of 2027.

About the Phase 1 Driving Simulation Trial

The randomized, double-blind, placebo- and active-controlled, three-way, crossover Phase 1 trial was designed to investigate the effects of evening doses of GlyphAllo on next-morning simulated driving performance in 33 healthy volunteers. Participants received GlyphAllo at bedtime and underwent driving performance assessments the following morning, approximately nine hours following GlyphAllo administration, consistent with established driving simulation trial methodologies. Driving performance was assessed using the Cognitive Research Corporation Driving Simulator-MiniSim, a widely accepted and validated tool used in clinical development. The primary endpoint was Standard Deviation of Lateral Position (SDLP), a gold standard measure of lane weaving commonly used in clinical trials to evaluate driving impairment. SDLP was assessed on Day 2 following a single 250 mg dose and then on Day 5 following multiple-day dosing of GlyphAllo at 375 mg. The trial also included a 7.5 mg dose of zopiclone as a positive control. GlyphAllo, including the 375 mg dose, the highest dose being evaluated in the ongoing Phase 2b BUOY-1 trial, has previously demonstrated desirable pharmacokinetics and pharmacodynamics, and a favorable safety and tolerability profile in Phase 1 and Phase 2a clinical trials.

About GlyphAllo (SPT-300 or Glyph Allopregnanolone)

GlyphAllo (SPT-300 or Glyph Allopregnanolone) is a novel, Glyphed oral prodrug of allopregnanolone, an endogenous molecule that has been clinically validated in third-party trials for the treatment of postpartum depression, or PPD, a form of major depressive disorder (MDD), that shares symptomatology with MDD, as a rapidly acting antidepressant with anxiolytic and sleep-promoting effects. GlyphAllo is designed to overcome bioavailability limitations of allopregnanolone and deliver rapid and durable efficacy in MDD. Seaport has demonstrated in a Phase 1 clinical trial that GlyphAllo reaches therapeutically relevant exposures with oral dosing, and in a Phase 2a clinical trial, GlyphAllo demonstrated initial proof-of-concept with an objective biomarker of stress in healthy volunteers and a favorable tolerability profile. Seaport is actively enrolling patients in BUOY-1, a two-arm, global, randomized, double-blind, placebo-controlled, potentially registration-enabling Phase 2b trial investigating the safety and efficacy of GlyphAllo in patients with MDD with or without anxious distress. Topline data from the BUOY-1 trial are expected in the first half of 2027.

About Seaport Therapeutics

Seaport Therapeutics (Nasdaq: SPTX) is a clinical-stage therapeutics company focused on inventing and developing new medicines for patients with depression, anxiety, and other debilitating neuropsychiatric disorders. Through its differentiated approach, the Company identifies clinically validated mechanisms with established efficacy and safety which had historically been limited by high first-pass metabolism, low bioavailability, and/or side effects. Seaport applies its proprietary Glyph™ platform to overcome those limitations and invent innovative oral therapies. With an experienced team of industry leaders, Seaport has a proven track record in neuropsychiatry drug discovery and development and delivering successful business outcomes. Seaport aims to develop novel, leading treatment options that will make a significant impact for patients and their families. For more information, please visit www.seaporttx.com.