Issue of Equity and Total Voting Rights

The Company today announces in respect of the month ended 31 October 2025, the issue of 1,704,751 ordinary shares of £0.0001 each ("Ordinary Shares"), following the exercise of options granted under the Company's share option plans and issuance of shares under certain of the Company's remuneration schemes.

Such Ordinary Shares were also admitted to the Official List of the Financial Conduct Authority ("FCA") and to trading on the London Stock Exchange's main market for listed securities under the Company's block listing facility. Following this issue, the Company has the ability to admit a further 7,040,672 Ordinary Shares under its block listing facility.

In accordance with the FCA's Disclosure Guidance and Transparency Rule 5.6.1, the Company announces that as at 31 October 2025, the Company's issued share capital consisted of 965,484,532 Ordinary Shares. The Company did not hold any shares in treasury. Accordingly, the total number of voting rights in the Company as at 31 October 2025 is 965,484,532. This figure may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the FCA's Disclosure Guidance and Transparency Rules.