Issue of Equity and Total Voting Rights

The Company today announces in respect of the period from 1 October to 14 October 2024, the issue of 12,566,031 ordinary shares of £0.0001 each, following:

• the issue of 12,500,789 ordinary shares to satisfy the vesting of awards under the Oxford Nanopore Technologies Limited Long-Term Incentive Plan 2021; and
• the exercise of options granted under the Company's share option plans and issuance of shares under certain of the Company's remuneration schemes and such ordinary shares were admitted to the Official List of the Financial Conduct Authority ("FCA") and to trading on the London Stock Exchange's main market for listed securities under the Company's block listing facility. Following this issue, the Company has the ability to admit a further 65,242 ordinary shares under its block listing facility.

In accordance with the FCA's Disclosure Guidance and Transparency Rule 5.6.1, the Company announces that as at 14 October 2024, the Company's issued share capital consisted of 954,021,220 ordinary shares, one class A limited anti-takeover ("LAT") share of £1.00, one class B LAT share of £1.00 and one class C LAT share of £1.00 and the Company will not hold any shares in treasury. Only the ordinary shares are voting shares and each such ordinary share carries one vote per ordinary share. As outlined in the Company's IPO Prospectus, the LAT shares could carry their rights for up to three years from the date of admission. Therefore, on 5 October 2024, the LAT shares ceased to carry any of their rights. Accordingly, the total number of voting rights in the Company as at 14 October 2024 is 954,021,220. This figure may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the FCA's Disclosure Guidance and Transparency Rules.