Issue of Equity and Total Voting Rights

The Company today announces in respect of the period from 1 June to 21 June 2024, the issue of 11,097,812 ordinary shares of £0.0001 each, following:

• the issue of 11,041,901 ordinary shares to satisfy the vesting of awards under Oxford Nanopore's Long Term Incentive Plan; and
• the exercise of options granted under the Company's share option plans and issuance of shares under certain of the Company's remuneration schemes and such ordinary shares were admitted to the Official List of the Financial Conduct Authority ("FCA") and to trading on the London Stock Exchange's main market for listed securities under the Company's block listing facility. Following this issue, the Company has the ability to admit a further 19,436,423 ordinary shares under its block listing facility.

In accordance with the FCA's Disclosure Guidance and Transparency Rule 5.6.1, the Company announces that as at 21 June 2024, the Company's issued share capital consisted of 873,921,325 ordinary shares, one class A limited anti-takeover ("LAT") share of £1.00, one class B LAT share of £1.00 and one class C LAT share of £1.00 and the Company will not hold any shares in treasury. Only the ordinary shares are voting shares and each such ordinary share carries one vote per ordinary share. Accordingly, the total number of voting rights in the Company as at 21 June 2024 is 873,921,325. This figure may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the FCA's Disclosure Guidance and Transparency Rules.