Directorate Change

London, UK – 22 September 2026, hVIVO plc (AIM: HVO), a purpose-built, full-service international clinical development partner and the world leader in human challenge trials, today announces the following changes to the Board as part of the ongoing evolution of its composition.

• Appointment of Caroline Shaw, CBE as Independent Non-Executive Director, effective from 1 October 2026. Caroline will also serve as Chair of the Remuneration Committee and as a member of the Audit Committee
• Elaine Sullivan to step down as Independent Non-Executive Director, effective from 1 October 2026

Appointment of Caroline Shaw, CBE: Caroline brings more than 30 years’ senior healthcare leadership experience across the NHS, independent healthcare, digital health and life sciences. She has held Chief Executive and board-level roles in both the public and private sectors, with expertise spanning strategy, clinical governance, operational transformation and commercial growth.

Her prior roles include Chief Executive Officer of Evergreen Life where she led a successful turnaround to profitability; Chief Executive Officer of Queen Elizabeth Hospital King’s Lynn NHS Foundation Trust; Chief Operating Officer / Deputy Chief Executive Officer of Nottingham University Hospitals NHS Trust; and Chief Executive Officer of The Christie NHS Foundation Trust.

Resignation of Elaine Sullivan: Concurrently, Elaine Sullivan will step down as an independent Non-Executive Director. Elaine joined the Board of hVIVO (then part of Open Orphan) in November 2020 and has previously served as Senior Independent Director and Chair of the Remuneration Committee.

Shaun Chilton, Non-Executive Chair of hVIVO plc, said:

“On behalf of the Board, I would like to thank Elaine for her contribution to hVIVO over the past six years during a period of strategic transformation. We wish her every success for the future.

"We are delighted to welcome Caroline Shaw to the Board. Her extensive clinical, operational and commercial leadership experience will be valuable as we continue to develop hVIVO’s broader, integrated clinical development platform and realise the significant opportunities it has to offer.”

Additional Information on the Board Appointment

The following additional information is provided with regards to the appointment of Caroline Sarah Shaw, aged 59, in accordance with Rule 17 and Schedule 2(g) of the AIM Rules for Companies:

Omnes Group Ltd

Omnes Healthcare Ltd

Queen Elizabeth Hospital King's Lynn NHS Foundation (Trust)

Caroline Shaw does not hold any shares or options in the Company. There are no further disclosures required under Rule 17 and Schedule 2(g) of the AIM Rules for Companies.